Odd that we should have something in common. I'm a huge fan of Sinfest. Been reading it since roughly late 2000. It was actually one of Pappy's former roommates that showed me it. It is probably one of the best comics every created. I especially love how they portray God (just a big thumb in the sky with a great sense of humor) and Seymour.
Some other great comics are Get Fuzzy and for the uber geeks out there Penny Arcade and Warbucket.